肝臟在人體內可利用本身的細胞色素（cytonchrome P450, CYP）系統結合營養素的作用，將體內脂溶性毒素排出體外，細胞色素P450為phase l解毒系統反應中負責外來物，例如藥物、致癌物、食品添加物及環境污染物等之氧化反應的酵素，這過程就是俗稱的解毒。最近相關研究表示，高抗氧化植物-台灣香檬中的陳皮素可抑制肝微粒體中多種 CYP 酶的活性，能減少飲食誘發的非酒精性脂肪肝疾病中的肝脂肪變性，並改變藥物代謝酶和轉運蛋白。#台灣香檬
How is the liver detoxified?
In the human body, the liver can use its own cytochrome (cytonchrome P450, CYP) system to combine nutrients to excrete fat-soluble toxins from the body. Cytochrome P450 is responsible for the elimination of foreign substances such as drugs, carcinogens, food additives and environmental pollutants in the phase l detoxification system reaction. This process is commonly known as detoxification. Recent studies have shown that nobiletin, a high-antioxidant plant-Taiwanese lemon (Citrus depressa), can inhibit the activity of various CYP enzymes in liver microsomes, reduce hepatic steatosis in diet-induced non-alcoholic fatty liver disease and change drug-metabolizing enzymes and transport proteins.
REF:
https://pubs.rsc.org/en/content/articlelanding/2022/fo/d1fo03597e/unauth
https://www.foodnext.net/news/newsnow/paper/5111339114